PhD defense of Thomas BUGEA
Thomas BUGEA has defended his PhD thesis entitled Visualising the self-assembly mechanisms of icosahedral viruses through fluorescence microscopy at the single molecule level under the supervision of Karen PERRONET and …
PhD defense of Kalouna KRA
Kalouna KRA has defended her PhD thesis entitled Structural study at high spatio-temporal resolution of the effects of hepatitis B virus capsid assembly modulators under the supervision of Stéphane BRESSANELLI …
Antivirals alter the elastic properties of Hepatitis B Virus capsids
More than 292 million people are chronically infected with the Hepatitis B Virus (HBV), mainly in Africa and South Asia, due to the lack of systematic vaccination. HBV causes severe pathologies such as liver cirrhosis and hepatocellular carcinoma, sometimes leading to the death of almost a million patients …
Sample formation for cryo-EM can be understood from a physico-chemical characterisation of liquid films and interfaces
Cryo electron microscopy (cryo-EM) has become an effective and straightforward approach to determine the structure of macromolecules in solution, trapped within a thin film (a few tens of nanometres) vitrified …
PhD defense of Mohamad Harastani
Mohamad HARASTANI has defended his PhD thesis entitled “Image analysis method development for in vitro and in situ cryo electron tomography studies of conformational variability of biomolecular complexes: case of …
Weaker attraction forces in curved DNA condensates
DNA packaging within viruses, chromosomes or nano-devices leads to extremely compact assemblies where not only high density but also very high curvature prevail. Yet DNA is a rather stiff filament, …
How a virus self-organizes while correcting its errors
RNA viruses are a family of infectious agents with sometimes dramatic health and economic consequences such as those we are currently experiencing. Over the course of a life cycle, viral …
PhD defense of Maelenn Chevreuil
Maelenn CHEVREUIL has defended her PhD thesis entitled Self-assembly and disassembly dynamical phenomena in icosahedral viruses under the supervision of Stéphane BRESSANELLI and Guillaume TRESSET on February 24, 2020. The …
Nucleosome conformational variability in situ and in vitro
In Eukaryotes, DNA is regularly wound into a left-handed super-helix around the histone octamer to form a chain of nucleosomes. Atomic structures have been obtained by crystallography of engineered nucleosomes. …
How do icosahedral RNA viruses package their genome?
In collaboration with the Institute of Integrative Biology of the Cell (I2BC), the Laboratoire Léon Brillouin and the European Synchrotron Radiation Facility, our team has elucidated the nonequilibrium self-assembly dynamics …